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The immunoblot results revealed that CSD significantly depressed the phosphorylated Nrf2 (p-Nrf2) activation, and subsequently reduced the downstream anti-oxidative enzymes activities (i.e., SOD1 and GPx) (Figures 3A,C)

[3] Deficiency of vitamin B leads to impaired function of PLP-dependent enzymes, which can manifest as neurological, hematological, and dermatological symptoms